How to solve this situation! different results of same colony

  • Dear friends,


    Today I received several results of ITS sequencing of moulds. This post is specifically about a Cladosporium where the same colony was subculture into two different plates (U11a and U11b), and I submitted both for sequencing. The following results are received (I have fasta / ab1 files for both):

    U11a = ok, 100% Cladosporium tenuissimum MK513837, C. cladosporioides MF475952, Hanseniaspora uvarum MG250496

    U11b = ok, 100% Cladosporium cladosporioides MT466517,C.cubuliforme MT312738


    So I have a tie (undecided) between C.cladosporioides and Cladosporium tenuissimum.


    How can I decide which is the one???

    1. Morphological examination (can it tell the difference between the two) ?

    2. Do other molecular tests (LSU ...???)

    3. Edit the sequences and repeat the phylogeny on BLAST/MEga-X

    4. Plate on different media?


    I prefer the cheaper options (hence avoid doing more tests! unless there are other cheaper options!)


    I am an eager amateur